She achieved massive commercial success later that year with the family drama Aanandham (2001), directed by N. Lingusamy. This performance solidified her reputation as a reliable talent for family-oriented films. Sneha followed this up with landmark commercial hits:

| Year | Title (Language) | Notable Role / Notes | | :--- | :--- | :--- | | 2000 | Ingane Oru Nilapakshi (Malayalam) | Debut film | | 2001 | Ennavale (Tamil) | First Tamil release | | 2001 | Priyamaina Neeku (Telugu) | Telugu debut | | 2001 | Aanandham (Tamil) | First commercial success | | 2002 | Unnai Ninaithu (Tamil) | Won Filmfare Award for Best Supporting Actress | | 2002 | Virumbugiren (Tamil) | Won Tamil Nadu State Film Award for Best Actress | | 2003 | Vaseegara (Tamil) | Co-starred with Vijay | | 2003 | Parthiban Kanavu (Tamil) | Played a dual role | | 2004 | Autograph (Tamil) | Critically acclaimed performance | | 2004 | Vasool Raja MBBS (Tamil) | Co-starred with Kamal Haasan | | 2005 | Radha Gopalam (Telugu) | Won Nandi Special Jury Award | | 2006 | Pudhupettai (Tamil) | Cult-classic, gritty role | | 2006 | Sri Ramadasu (Telugu) | Co-starred with Nagarjuna | | 2008 | Pirivom Santhippom (Tamil) | Won Tamil Nadu State Film Award for Best Actress |

Sneha plays Kamala, a widow who confronts her former lover. Her restrained, heartbreaking performance won her a State Award. Clips of this scene are widely shared as an acting masterclass.

: Her talent has been formally recognized with several prestigious awards, including the Filmfare Award for Best Actress – Tamil and Tamil Nadu State Film Awards , cementing her status as one of the finest actors in the industry.

A blockbuster comedy where she shared the screen with legends Kamal Haasan and Simran, displaying excellent comedic timing.

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