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| Patent | Priority date | Main claims | |--------|---------------|-------------| | | 15 Jan 2022 | Claims a series of fluoro‑aryl pyrimidine kinase inhibitors covering JUQ‑470, with specific substitution patterns on the aromatic ring and heterocycle. | | US2023/098765 | 3 Mar 2023 | Claims the pharmacological use of JUJ‑470 (and analogs) for treatment of FGFR‑driven and angiogenesis‑dependent cancers. | | US2024/014321 (filed 2024) | 21 Jun 2024 | Claims combination regimens of JUQ‑470 with immune checkpoint inhibitors (PD‑1/PD‑L1 antibodies). | | | US2023/098765 | 3 Mar 2023 |
JUQ‑470’s approach aims to fill a niche where tumors rely on both FGFR‑driven proliferation and VEGF‑driven angiogenesis.
The inclusion of CAN‑bus and an optional Ethernet module means the device can be in a modern Industry 4.0 environment. Remote diagnostics, over‑the‑air firmware updates, and real‑time telemetry become trivial.